Note: CCRD academic staffs’ name are highlighted in black.



Kwan HY, Fu   X, Liu B, Chao X, Chan CL, Cao HH, Su T, Tse AK, Fong WF Yu ZL (Corresponding Author).   Subcutaneous adipocytes promote melanoma cell growth by activating Akt   signaling pathway: role of palmitic acid. J Biol Chem. 2014;289(44):30525-37.


Cao HH, Tse   AK, Kwan HY, Yu H, Cheng CY, Su T, Fong WF, Yu ZL (Corresponding Author).   Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem   Pharmacol. 2014;87(3):424-34.


Tse AW, Cao   HH, Cheng CY, Kwan HY, Yu H, Fong WF, Yu ZL (Corresponding Author).   Indomethacin Sensitizes TRAIL-Resistant Melanoma cells to TRAIL-induced   Apoptosis through ROS-mediated Up-regulation of Death Receptor 5 and   Down-regulation of Survivin. J Invest Dermatol. 2014;134(5):1397-407.


Kwan HY, Chao   XJ, Su T, Fu XQ, Tse AK, Fong WF, Yu ZL (Corresponding Author). The anti-cancer and   anti-obesity effects of Mediterranean diet. Crit Rev Food Sci Nutr. 2014; doi: 10.1080/10408398.2013.852510.


Fu XQ, Chou GX,   Kwan HY, Tse KW, Zhao LH, Yuen TK, Cao HH, Yu H, Chao XJ, Su T, Cheng CY, Sun   XG, Yu ZL (Corresponding Author).   Inhibition of STAT3 signaling contributes to the anti-melanoma action   of atractylenolide II. Exp Dermatol.   2014;23(11):855-7.


Su T, Yu H, Kwan HY, Ma XQ, Cao HH,   Cheng CY, Leung AK, Chan CL, Li WD, Cao H, Fong WF, Yu ZL (Corresponding Author). Comparisons   of the chemical profiles, cytotoxicities and anti-inflammatory effects of raw   and rice wine-processed Herba Siegesbeckiae. J Ethnopharmacol. 2014;156:365-9.


Tse AK, Chow KY, Cao HH, Cheng CY,   Kwan HY, Yu H, Zhu GY, Wu YC, Fong WF, Yu ZL (Corresponding Author). The Herbal Compound   Cryptotanshinone Restores Sensitivity in Cancer Cells that are Resistant to   the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. J Biol Chem. 2013;288(41):29923-33.


Ma XQ, Man Leung AK, Chan CL, Su T,   Li WD, Li SM, Fun Fong DW, Yu ZL (Corresponding Author). UHPLC UHD Q-TOF MS/MS   analysis of the impact of sulfur fumigation on the chemical profile of   Codonopsis Radix (Dangshen). Analyst.   2013;139(2):505-16.


Kwan HY, Hu YM, Chan CL, Cao HH,   Cheng CY, Pan SY, Tse KW, Wu YC, Yu ZL (Corresponding Author), Fong WF. Lipidomics   identification of metabolic biomarkers in chemically induced   hypertriglyceridemic mice. J Proteome   Res. 2013;12(3):1387-98.


Kwan HY, Yang Z, Fong WF, Hu YM, Yu   ZL (Corresponding Author),   Hsiao WL. The anticancer effect of oridonin is mediated by fatty acid   synthase suppression in human colorectal cancer cells. J Gastroenterol. 2013;48(2):182-92.


Kwan HY, Fong WF, Yang Z, Yu ZL (Corresponding Author),   Hsiao WL. Inhibition of DNA-dependent protein kinase reduced palmitate and   oleate-induced lipid accumulation in HepG2 cells. Eur J Nutr. 2013;52(6):1621-30.


Wang H, Ye Y, Yu ZL (Corresponding Author).   Proteomic and functional analyses demonstrate the involvement of oxidative   stress in the anticancer activities of oridonin in HepG2 cells. Oncol Rep. 2014;31(5):2165-72.


Chao XJ, Chen ZW, Liu AM, He XX, Wang   SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB. Effect of   tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer,   against oxidative-stress-induced cell death in HT22 hippocampal neurons:   involvement of Nrf2/HO-1 pathway. CNS   Neurosci Ther. 2014;20(9):840-50.


Zhang Y, Pan SY, Zhou SF, Wang XY,   Sun N, Zhu PL, Chu ZS, Yu ZL, Ko   KM. Time and dose relationships between schisandrin B- and schisandrae   fructus oil-induced hepatotoxicity and the associated elevations in hepatic   and serum triglyceride levels in mice. Drug   Des Devel Ther. 2014;8:1429-39.


Pan SY, Litscher G, Chan K, Yu ZL, Chen HQ, Ko KM. Traditional   medicines in the world: where to go next? Evid Based Complement Alternat Med. 2014;2014:739895.


Su T, Mao C, Yin F, Yu Z, Lin Y, Song Y, Lu T. Effects of   unprocessed versus vinegar-processed Schisandra chinensis on the activity and   mRNA expression of CYP1A2, CYP2E1 and CYP3A4 enzymes in rats. J Ethnopharmacol. 2013;146(3):734-43.


Pan SY, Jia ZH, Zhang Y, Yu Q, Wang   XY, Sun N, Zhu PL, Yu ZL, Ko KM.   Novel mouse model of combined hyperlipidemia associated with steatosis and   liver injury by a single-dose intragastric administration of schisandrin   B/cholesterol/bile salts mixture. J   Pharmacol Sci. 2013;123(2):110-9.


Tan Y, Li J, Liu X, Ko J, He X, Lu C,   Liu Z, Zhao H, Xiao C, Niu X, Zha Q, Yu   Z, Zhang W, Lu A. Deciphering the differential toxic responses of Radix   aconiti lateralis praeparata in healthy and hydrocortisone-pretreated rats   based on serum metabolic profiles. J   Proteome Res. 2013;12(1):513-24.


Pan SY, Yu Q, Zhang Y, Wang XY, Sun   N, Yu ZL, Ko KM. Dietary Fructus   Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile   in normal and hypercholesterolemic mice, with attention to hepatotoxicity. Lipids Health Dis. 2012;11:120.


Pan SY, Gao SH, Zhou SF, Tang MK, Yu ZL, Ko KM. New perspectives on   complementary and alternative medicine: an overview and alternative therapy. Altern Ther Health Med.   2012;18(4):20-36.


Huo L, Wu R, Yu   Z, Zhai Y, Yang X, Chan TC, Yeung JT, Kan J, Liang C. The Rix1   (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing   independent of their roles in ribosome biogenesis. Cell Cycle. 2012;11(7):1325-39.


Xu L, Chan CO, Lau CC, Yu Z, Mok DK, Chen S. Simultaneous   determination of eight anthraquinones in Semen Cassiae by HPLC-DAD. Phytochem Anal. 2012;23(2):110-6.


Tsang TF, Ye Y, Tai WC, Chou GX,   Leung AK, Yu ZL, Hsiao WL.   Inhibition of the p38 and PKA signaling pathways is associated with the   anti-melanogenic activity of Qian-wang-hong-bai-san, a Chinese herbal   formula, in B16 cells. J   Ethnopharmacol. 2012;141(2):622-8.


Guo D, Xu L, Cao X, Guo Y, Ye Y, Chan   CO, Mok DK, Yu ZL (Corresponding Author),   Chen S. Anti-inflammatory activities and mechanisms of action of the   petroleum ether fraction of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2011;138(3):717-22.


Chu JH, Wang H, Ye Y, Chan PK, Pan   SY, Fong WF, Yu ZL (Corresponding Author).   Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in   L-02 cells. World J Gastroenterol.   2011;17(19):2379-88.


Pan SY, Guo BF, Zhang Y, Yu Q, Yu   ZL (Corresponding Author),   Dong H, Ye Y, Han YF, Ko KM. Tacrine treatment at high dose suppresses the   recognition memory in juvenile and adult mice with attention to   hepatotoxicity. Basic Clin Pharmacol   Toxicol. 2011;108(6):421-7.


Yan Ye, Chou GX, Hui Wang, Chu JH,   Fong WF, Yu ZL (Corresponding Author).   Effects of sesquiterpenes isolated from largehead atractylodes rhizome on   growth, migration, and differentiation of B16 melanoma cells. Integr Cancer Ther.   2011;10(1):92-100.


Ye Y, Wang H, Chu JH, Chou GX, Chen   SB, Mo H, Fong WF, Yu ZL (Corresponding Author).   Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma   cells. J Ethnopharmacol.   2011;136(1):279-82.


Ye Y, Wang H, Chu JH, Chou GX, Yu   ZL (Corresponding Author).   Activation of p38 MAPK pathway contributes to the melanogenic property of   apigenin in B16 cells. Exp Dermatol.   2011;20(9):755-7.


Wang H, Ye Y, Pan SY, Zhu GY, Li YW,   Fong DW, Yu ZL (Corresponding Author).   Proteomic identification of proteins involved in the anticancer activities of   oridonin in HepG2 cells. Phytomedicine.   2011;18(2-3):163-9.


Wang H, Ye Y, Chu JH, Zhu GY, Fong   WF, Yu ZL (Corresponding Author).   Proteomic and functional analyses reveal the potential involvement of   endoplasmic reticulum stress and α-CP1 in the anticancer activities of   oridonin in HepG2 cells. Integr Cancer   Ther. 2011;10(2):160-7.


Fang HY, Chen SB, Guo DJ, Pan SY, Yu   ZL (Corresponding Author).   Proteomic identification of differentially expressed proteins in   curcumin-treated MCF-7 cells. Phytomedicine.   2011;18(8-9):697-703.


Zhu GY, Li YW, Tse AK, Hau DK, Leung   CH, Yu ZL, Fong WF.   20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis   through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells. Eur J Pharmacol. 2011;668(1-2):88-98.


Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL, Fong WF. Furanodienone   inhibits cell proliferation and survival by suppressing ERα signaling in   human breast cancer MCF-7 cells. J   Cell Biochem. 2011;112(1):217-24.


Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL, Fong WF. Furanodienone induces   cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in   HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011;68(5):1315-23.


Pan SY, Dong H, Guo BF, Zhang Y, Yu ZL, Fong WF, Han YF, Ko KM.   Effective kinetics of schisandrin B on serum/hepatic triglyceride and total   cholesterol levels in mice with and without the influence of fenofibrate. Naunyn Schmiedebergs Arch Pharmacol.   2011;383(6):585-91.


Pan SY, Chen SB, Dong HG, Yu ZL, Dong JC, Long ZX, Fong WF, Han   YF, Ko KM. New perspectives on chinese herbal medicine (zhong-yao) research   and development. Evid Based Complement   Alternat Med. 2011;2011:403709.


Hu Y, Yu Z, Yang ZJ, Zhu G, Fong W. Comprehensive chemical analysis of   Venenum Bufonis by using liquid chromatography/electrospray ionization tandem   mass spectrometry. J Pharm Biomed Anal.   2011;56(2):210-20.


Hu YM, Yu ZL, Fong WF. Stereoselective biotransformation of timosaponin   A-III by Saccharomyces cerevisiae. J   Microbiol Biotechnol. 2011;21(6):582-9.


Zhu GY, Li YW, Hau DK, Jiang ZH, Yu ZL, Fong WF. Protopanaxatriol-type   ginsenosides from the root of Panax ginseng. J Agric Food Chem. 2011;59(1):200-5.


Zhu GY, Li YW, Hau DK, Jiang ZH, Yu ZL, Fong WF. Acylated   protopanaxadiol-type ginsenosides from the root of Panax ginseng. Chem Biodivers. 2011;8(10):1853-63.


Yi T, Chen HB, Zhao ZZ, Yu ZL, Jiang ZH. Comparison of the   chemical profiles and anti-platelet aggregation effects of two "Dragon's   Blood" drugs used in traditional Chinese medicine. J Ethnopharmacol. 2011;133(2):796-802.


Tse AK, Zhu GY, Wan CK, Shen XL, Yu ZL, Fong WF.   1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear   factor kappa B in breast cancer cells. Mol   Immunol. 2010;47(9):1728-38.


Ye Y, Chu JH, Wang H, Xu H, Chou GX,   Leung AK, Fong WF, Yu ZL (Corresponding Author).   Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of   San-bai-tang, a Chinese herbal formula, in B16 cells. J Ethnopharmacol. 2010;132(2):533-5.


Ye Y, Chou GX, Mu DD, Wang H, Chu JH,   Leung AK, Fong WF, Yu ZL (Corresponding Author).   Screening of Chinese herbal medicines for antityrosinase activity in a cell   free system and B16 cells. J   Ethnopharmacol. 2010;129(3):387-90.


Ye Y, Chou GX, Wang H, Chu JH, Yu   ZL (Corresponding Author).   Flavonoids, apigenin and icariin exert potent melanogenic activities in   murine B16 melanoma cells. Phytomedicine.   2010 Dec 15;18(1):32-5.


Wang H, Chan PK, Pan SY, Kwon KH, Ye Y, Chu JH,   Fong WF, Tsui WM, Yu ZL (Corresponding Author).   ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and   human nonalcoholic fatty livers. J   Cell Biochem. 2010;110(6):1447-56.


Wang H, Ye Y, Chui JH, Zhu GY, Li YW,   Fong DW, Yu ZL (Corresponding Author).   Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53   signaling pathways in HepG2 cells. Oncol   Rep. 2010;24(3):647-51.


Copyright © 2015 Consun Chinese Medicines Research Centre For Renal Diseases